Wnt Signaling Specifies Anteroposterior Progenitor Zone Identity in the Drosophila Visual Center

Takumi Suzuki1,*, Olena Trush2,*, Tetsuo Yasugi3, Rie Takayama3,4, and Makoto Sato1,2,3,4 1Laboratory of Developmental Neurobiology, Brain/Liver Interface Medicine Research Center, 2Graduate School of Medical Sciences, and 3Mathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa University, Ishikawa 920-8640, Japan, and 4Core Research for Evolutional Science and Technology, JST, Saitama 332-0012, Japan Author contributions: T.S. and M.S. designed research; T.S., O.T., T.Y., and R.T. performed research; T.S. analyzed data; T.S. and M.S. wrote the paper. ↵*T.S. and O.T. contributed equally to this work. Abstract During brain development, various types of neuronal populations are produced from different progenitor pools to produce neuronal diversity that is sufficient to establish functional neuronal circuits. However, the molecular mechanisms that specify the identity of each progenitor pool remain obscure. Here, we show that Wnt signaling is…


Link to Full Article: Wnt Signaling Specifies Anteroposterior Progenitor Zone Identity in the Drosophila Visual Center