Tunnelling Nanotubes Between Neurons Enable the Spread of Parkinson’s Disease Via …

Paris, France (Scicasts) — Scientists from the Institut Pasteur have demonstrated the role of lysosomal vesicles in transporting α-synuclein aggregates, responsible for Parkinson’s and other neurodegenerative diseases, between neurons. These proteins move from one neuron to the next in lysosomal vesicles which travel along the “tunnelling nanotubes” between cells. These findings were published in The EMBO Journal on Aug. 22, 2016. Synucleinopathies, a group of neurodegenerative diseases including Parkinson’s disease, are characterized by the pathological deposition of aggregates of the misfolded α-synuclein protein into inclusions throughout the central and peripheral nervous system. Intercellular propagation (from one neuron to the next) of α-synuclein aggregates contributes to the progression of the neuropathology, but little was known about the mechanism by which spread occurs. In this study, scientists from the Membrane Traffic and…


Link to Full Article: Tunnelling Nanotubes Between Neurons Enable the Spread of Parkinson’s Disease Via …