Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD 67 expression in …

Citation: Translational Psychiatry (2016) 6, e723; doi:10.1038/tp.2015.224Published online 26 January 2016 Top of page Introduction Schizophrenia (SZ) is a debilitating mental disorder, which affects approximately 1% of the world population and is responsible for about 3% of the disease-related economic burden.1 SZ is characterized by a complex interaction between genetic predisposition and environmental influences that may lead to disturbances of early brain development.2, 3 GABA neurons in the cortex and hippocampus of SZ are subject to pathophysiological changes whose key feature is a decrease in glutamate decarboxylase (GAD) mRNA4, 5 and -immunoreactivity.6 The resulting loss of GABAergic activity disrupts cortical gamma oscillations and may account for the cognitive deficits seen in SZ.7 Understanding the molecular mechanisms of GABA dysfunction in SZ is critical for the development of effective new treatments for the…


Link to Full Article: Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD 67 expression in …