Thesis Defense: Shrivats Iyer

June 23, 2016 – 9:00am Clark Center S361 [Not] lost in translation: Optogenetic and chemogentic control of sensory circuits Thesis Defense by Shrivats Iyer Mentor: Scott Delp Abstract:  This dissertation has two primary purposes: To increase our ability to control the neural circuits that control pain perception, ideally in a way that can be applied to treat people with chronic pain disorders.  To improve our understanding of the spinal circuits that process sensory stimuli.  Towards these ends, we performed three major studies: We initially asked whether optogenetic techniques could be used to control peripheral pain circuits. We developed viral methods to specifically express stimulatory and inhibitory opsins in unmyelinated primary afferent neurons, and characterized the resulting transduction profile. We found that transdermal illumination could be used to non-invasively stimulate or…


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