The Proinflammatory Cytokine Interleukin 18 Regulates Feeding by Acting on the Bed Nucleus of …

Walter Francesconi1, Manuel Sánchez-Alavez1,2, Fulvia Berton2,3, Silvia Alboni4, Cristina Benatti4, Simone Mori2, William Nguyen2, Eric Zorrilla5, Gianluca Moroncini6, Fabio Tascedda4, and Bruno Conti1,2 1Molecular and Cellular Neuroscience Department and 2Department of Chemical Physiology, and 5CNAD, The Scripps Research Institute, La Jolla, California, 3Department of Biology, University of Pisa, Italy, 4Department of Life Sciences, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy, and 6Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy Author contributions: W.F., F.B., and B.C. designed research; W.F., M.S.-A., F.B., S.A., C.B., S.M., and W.N. performed research; W.F., M.S.-A., S.A., E.Z., and B.C. analyzed data; W.F., M.S.-A., S.A., E.Z., G.M., F.T., and B.C. wrote the paper. Abstract The proinflammatory cytokine IL-18 has central anorexigenic effects and was proposed to contribute to loss of…


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