The effects of compound stimulus extinction and inhibition of noradrenaline reuptake on the …

Citation: Translational Psychiatry (2015) 5, e630; doi:10.1038/tp.2015.130Published online 1 September 2015 Top of page Introduction The high incidence of relapse, even following long periods of abstinence, is a major obstacle for successful treatment of drug and alcohol abuse.1 Situational cues associated with drinking are powerful reminders of the effects of alcohol and can trigger craving and drug-seeking behaviors even after long periods of abstinence.2, 3, 4, 5 Alcohol-associated cues are, therefore, a major factor contributing to increased risk of relapse and reducing the impact of these cues should reduce relapse rates. Behavioral extinction is one approach for reducing the influence of alcohol-related cues, in which repeated presentation of the cue without alcohol leads to a reduction in responses, such as craving, triggered by the cue. However, extinction-based treatments for addiction have had…


Link to Full Article: The effects of compound stimulus extinction and inhibition of noradrenaline reuptake on the …