Study identifies new trigger mechanism for fragile X syndrome in mice

A study published today in the Journal of Neuroscience led by Yongjie Yang of Tufts University School of Medicine identifies an astroglial trigger mechanism as contributing to symptoms of fragile X syndrome in mice. Fragile X syndrome (FXS) is a genetic disorder that arises from mutations in a gene on the X chromosome. It is the most common cause of inherited intellectual disability in humans and is associated with autism spectrum disorder. Previous research had associated the loss of a single protein, fragile X mental retardation protein (FMRP), as the predominant cause of FXS. Astroglia, a class of nervous system support cell, are abundant in the brain and help regulate neuronal signaling. They are implicated in several neurological disorders, including FXS, but little is known about how they become dysfunctional…


Link to Full Article: Study identifies new trigger mechanism for fragile X syndrome in mice