Researchers develop first animal-free platform for testing drug safety

Because their job is to eliminate drugs and other foreign compounds from the body, the kidneys are a main target for any toxic effects. Now, after finding an effective way of producing human kidney cells from stem cells, a team of scientists has developed the first animal-free screening platform that is capable of accurately predicting the toxic effects of compounds on the kidney.Kidney cells generated from stem cells untreated (top) or treated with aristolochic acid (bottom), a toxic compound widely used in traditional Chinese medicine and other herbal remedies, which is banned in many countries.Image credit: IBN Singapore In the journal Scientific Reports, scientists from the Institute of Bioengineering and Nanotechnology (IBN) in Singapore describe how they developed the platform using human induced pluripotent stem cells (iPSCs) and machine learning…


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