Re-Opening the Critical Window for Estrogen Therapy

Linda A. Bean1, Ashok Kumar1, Asha Rani1, Mike Guidi2, Awilda M. Rosario3, Pedro E. Cruz3, Todd E. Golde3, and Thomas C. Foster1 1Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32611, 2Noldus Information Technology, Leesburg, Virginia 20176, and 3Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, Florida 32610 Author contributions: L.A.B., A.K., and T.C.F. designed research; L.A.B., A.K., A.R., M.G., P.E.C., and A.M.R. performed research; T.E.G. contributed unpublished reagents/analytic tools; L.A.B., A.K., and T.C.F. analyzed data; L.A.B., A.K., and T.C.F. wrote the paper. Abstract A decline in estradiol (E2)-mediated cognitive benefits denotes a critical window for the therapeutic effects of E2, but the mechanism for closing of the critical window is unknown. We hypothesized that upregulating the expression…


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