Rapid Postnatal Expansion of Neural Networks Occurs in an Environment of Altered Neurovascular …

Mariel G. Kozberg, Ying Ma, Mohammed A. Shaik, Sharon H. Kim, and Elizabeth M. C. Hillman Laboratory for Functional Optical Imaging, Departments of Biomedical Engineering and Radiology, Mortimer B. Zuckerman Mind Brain Behavior Institute and Kavli Institute for Brain Science, Columbia University, New York, New York 10027 Author contributions: M.G.K. and E.M.C.H. designed research; M.G.K., Y.M., M.A.S., S.H.K., and E.M.C.H. performed research; M.G.K., Y.M., M.A.S., and E.M.C.H. analyzed data; M.G.K. and E.M.C.H. wrote the paper. Abstract In the adult brain, increases in neural activity lead to increases in local blood flow. However, many prior measurements of functional hemodynamics in the neonatal brain, including functional magnetic resonance imaging (fMRI) in human infants, have noted altered and even inverted hemodynamic responses to stimuli. Here, we demonstrate that localized neural activity in early…


Link to Full Article: Rapid Postnatal Expansion of Neural Networks Occurs in an Environment of Altered Neurovascular …