Preventive effects of minocycline in a neurodevelopmental two-hit model with relevance to …

Citation: Translational Psychiatry (2016) 6, e772; doi:10.1038/tp.2016.38Published online 5 April 2016S Giovanoli1,2,7, H Engler3,7, A Engler3, J Richetto4,5,6, J Feldon2, M A Riva4,5, M Schedlowski3 and U Meyer1,2,6 Top of page Introduction Converging evidence implicates a role of immune mechanisms in normal and pathological brain development.1, 2 The antenatal period is highly sensitive to the damaging effects induced by environmental insults, and therefore, considerable efforts have been made to explore the impact of immune-mediated adversities such as prenatal infection in neuropsychiatric and neurological disorders with developmental components.3 Besides schizophrenia,4 maternal exposure to infection and/or inflammatory processes is associated with increased risk of bipolar disorder,5 autism,6 mental retardation7 and cerebral palsy.8 Prenatal infection and/or inflammation may thus represent a general vulnerability factor for neurodevelopmental brain disorders, so that the specificity of subsequent neuropathology and psychopathological symptoms is likely to be influenced…


Link to Full Article: Preventive effects of minocycline in a neurodevelopmental two-hit model with relevance to …