PhD student in neuroscience: spreading mechanisms of proteinopathy in amyotrophic lateral …

The successful applicant will be working in Inserm unit U1118, under the supervision of Dr Dupuis, in collaboration with the laboratories of Dr Polymenidou (University of Zurich, Switzerland) and Pr Ludolph (University of Ulm, Germany).He/she will investigate the mechanisms of spreading of protein aggregation in ALS. This will be done using mouse genetics, using conditional knock-in mice developed and characterized in the laboratory. These genetic experiments will be combined with mouse phenotyping, as well as biochemistry, histology and molecular biology. Specifically, the PhD student will use Fus knock-in mice recently described in our recent study (Scekic-Zahirovic, EMBO Journal, 2016), and perform gain and loss of FUS mutations in the cerebral cortex of mice to identify how disease spreads from the motor cortex. Furthermore, the applicant will challenge the “prion-like” hypothesis…


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