NPY + -, but not PV + -GABAergic neurons mediated long-range inhibition from infra- to prelimbic …

Citation: Translational Psychiatry (2016) 6, e736; doi:10.1038/tp.2016.7Published online 16 February 2016R Saffari1,2, Z Teng1,2, M Zhang1,2, M Kravchenko1, C Hohoff1, O Ambrée1 and W Zhang1 Top of page Introduction Emotional memories and regulation of these are important for guiding adaptive behavior. Mental disorders, such as anxiety disorders including panic disorder and post-traumatic stress disorder, are thought to reflect deficits in regulation of emotional memories.1 While the amygdala has long been considered a site of storage of emotional memories, the prefrontal cortex (PFC) with its extensive connections to subcortical limbic areas and thalamus2, 3 has been suggested to be essential in the regulation of amygdala-dependent memories and fear expression, especially following extinction.4, 5, 6 Damages in the PFC have been found to lead to dramatic alterations of the capacity of mammals to cope emotionally with environmental changes, pointing to the…


Link to Full Article: NPY + -, but not PV + -GABAergic neurons mediated long-range inhibition from infra- to prelimbic …