Novel Biomarkers May Help Predict Response to Lupus Nephritis Therapy

Researchers have identified novel biomarkers for lupus nephritis (LN), a disease that affects several patients with systemic lupus erythematosus (SLE), according to a study published in the journal Arthritis & Rheumatology. The authors reported these biomarkers can accurately indicate disease development and predict therapeutic effectiveness. The study is titled “Development of Biomarker Models to Predict Outcomes in Lupus Nephritis” and was conducted by researchers from the Medical University of South Carolina. LN leads to kidney failure in up to 50% of patients within five years. The American College of Rheumatology guidelines for the treatment of LN recommend that induction therapy (first treatment given to a patient) must be changed when response to therapy has not occurred within 6 months. However, response to therapy is difficult to define in LN patients, and renal…


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