Noradrenaline involved in stress resilience, vulnerability to depression

A new study suggests that noradrenaline – also known as norepinephrine – may influence vulnerability to depression through its effect on dopamine neurons in the brain.The researchers found stopping the neurons from releasing noradrenaline made the animals systematically susceptible to depression when exposed to chronic stress. The new study – the first to find such a link – is the work of researchers from McGill University in Montréal, Canada, who report their findings in the journal Nature Neuroscience. Stressful life events – such as the death of a loved one, serious accident or losing one’s job – can trigger major depression, a common mental disorder that is characterized by loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, feelings of tiredness, sadness and poor…


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