New type of antidepressant found to act quickly in mice

IMAGE: This image shows pills. view more Credit: Public Domain The compound CGP3466B, already proven nontoxic for people, may effectively and rapidly treat depression, according to results of a study in mice. The Johns Hopkins Medicine neuroscientists who conducted the research say that the compound — previously shown to block cocaine craving in the brains of rodents — delivers antidepressant effects to mice within hours instead of weeks or months, like currently available antidepressants. The results of the study will be summarized Jan. 12 online in the journal Molecular Psychiatry. “One of the promising things about CGP3466B is that it targets a new network of proteins,” says Solomon Snyder, M.D., professor of neuroscience at the Johns Hopkins University School of Medicine. “That means it may work in patients who are unresponsive…


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