New Study Points to Cause of Debilitating Nerve Disease

La Jolla (Scicasts) — Scientists at The Scripps Research Institute (TSRI) and the Salk Institute for Biological Studies have discovered how a mutant protein triggers nerve damage in a subtype of Charcot-Marie-Tooth (CMT) diseases, a group of currently untreatable conditions that cause loss of function in a person’s hands and feet. The new research suggests future therapies may target this haywire protein, restoring nerve function in patients with CMT. “This is the first major advancement toward a molecular mechanistic understanding of CMT subtype CMT2D,” said TSRI Professor Xiang-Lei Yang, senior author of the new study with Samuel Pfaff, a neuroscience professor at the Salk Institute and a Howard Hughes Medical Institute investigator. “These findings will help us develop future diagnostics and treatments.” The research was published online in advance of…


Link to Full Article: New Study Points to Cause of Debilitating Nerve Disease