New research sheds light on neuronal communication

IMAGE: Presynaptic deletion of the two G-protein-coupled receptor kinase-interacting proteins (GITs), GIT1 and GIT2, at the mouse calyx of Held, leads to a large increase in the action potential (AP)-evoked release,… view more Credit: Mónica S. Montesinos and Samuel M. Young Jr./Max Planck Florida Institute for Neuroscience. Neurons communicate with each other through specialized structures called synapses. The information is transmitted in the form of synaptic vesicles that contain specific chemical messengers called neurotransmitters The amount and coordinated release of neurotransmitters regulates synaptic strength which is critical to maintain proper communication between neurons. To better understand and address a number of neurological disorders, we need a better understanding of the molecular mechanisms that regulate neuronal communication. A new study has revealed an important function of a class of presynaptic proteins previously implicated…


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