New Drug Target Could Prevent Tolerance and Addiction to Opioids, Neuroscience Study Finds

ATLANTA—Researchers have identified a brain mechanism that could be a drug target to help prevent tolerance and addiction to opioid pain medication, such as morphine, according to a study by Georgia State University and Emory University. Media Contact LaTina Emerson Public Relations Specialist    Georgia State University 404-413-1353lemerson1@gsu.edu The findings, published in the Nature journal Neuropsychopharmacology in August, show for the first time that morphine tolerance is due to an inflammatory response produced in the brain. This brain inflammation is caused by the release of cytokines, chemical messengers in the body that trigger an immune response, similar to a viral infection. Researchers’ results show blocking a particular cytokine eliminated morphine tolerance, and they were able to reduce the dose of morphine required to alleviate pain by half. “These results have important…


Link to Full Article: New Drug Target Could Prevent Tolerance and Addiction to Opioids, Neuroscience Study Finds