New Avenue for Thinking About Brain Development, Brain Tumours and Neurodevelopmental …

Boston, MA (Scicasts) — The genome of developing brain cells harbours 27 clusters or hotspots where its DNA is much more likely to break in some places than others, researchers from the Program in Cellular and Molecular Medicine (PCMM) at Boston Children’s Hospital, Harvard Medical School, and the Howard Hughes Medical Institute report in the journal Cell. Those hotspots appear in genes associated with brain tumours and a number of neurodevelopmental and neuropsychiatric conditions, raising new questions about these conditions’ origins, as well as how the brain generates a diversity of circuitry during development. The study’s roots reach back more than 30 years, when PCMM director and study senior author Dr. Frederick Alt, and his colleagues first started investigating the links between tumours, oncogenes, DNA breaks and DNA repair, particularly…


Link to Full Article: New Avenue for Thinking About Brain Development, Brain Tumours and Neurodevelopmental …