Neurochemical Signal Likely Missing in Parkinson’s Identified

Evanston, IL (Scicasts) — Two Northwestern University neuroscientists have identified the neurochemical signal likely missing in Parkinson’s disease by being the first to discover two distinctly different kinds of neurons that deliver dopamine to an important brain region responsible for both movement and learning/reward behaviour. “It has been dogma for decades that all dopamine neurons are somehow involved in both movement and reward, but this didn’t really make sense,” said Daniel A. Dombeck, the study’s senior author. “Now, it is so obvious in our recordings that there are different kinds of neurons. We can literally see this in behaving animals. Our findings will likely help answer many questions about Parkinson’s disease and other neurological mysteries.” Dombeck, an assistant professor of neurobiology in the Weinberg College of Arts and Sciences, conducted…


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