Neural circuitry feeding into the lateral hypothalamus, by Matthew Soleiman

At first blush, eating as a daily behavior may seem fairly straightforward. However, neuroscientists are still getting a handle on the complexities of how the brain controls eating – complexities which may explain how eating goes awry, such as in eating disorders. Much historical and present-day interest in feeding has revolved around the lateral hypothalamus (LHA), a nucleus that houses genetically diverse neuron populations, and one connected to an intimidating number of other brain regions. But thanks to current genetic technology, recent work has started to parse out the exact LHA circuitry that regulates feeding in rodents. A couple years ago, the lab of Garret Stuber (UNC-Chapel Hill) revealed that input from the extended amygdala to excitatory neurons of LHA controls feeding, while earlier this year, both the Stuber and…


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