Network neuroscience: developing a model of the human brain to study cognition and behavior

How does the brain produce cognition and behavior? Historically, much research has focused on gray matter anatomy and function because it is the cell bodies that create EEG signals, activate in fMRI studies, and produce movement and behavior when stimulated with electrical pulses. However, it is the white matter—the axonal connections—that connect distinct brain regions. It is those connections that are being increasingly considered vital to understanding the neural networks that underlie cognition and behavior. Network controllability refers to the possibility of guiding a system from an initial state to a desired final state with a proper set of inputs. The target state is chosen for its functional utility. The brain, which is commonly referred to as a network, with its nodes (neuronal ensembles) interlinked by anatomical wires (axons), is…


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