Nerve terminal nanofilaments control brain signalling

3D reconstruction showing three types of nanofilaments that connect to synaptic vesicles in the nerve terminals of excitatory synapses in the rat hippocampus. Reprinted with permission: Cole, A. A., et al., Journal of Neuroscience, 2016. This spectacular image – which took the best part of a year to create – shows the fine structure of a nerve terminal at high resolution, revealing, for the very first time, an intricate network of fine filaments that controls the movements of synaptic vesicles. The brain is soft and wet, with the consistency of a lump of jelly. Yet, it is the most complex and highly organized structure that we know of, containing hundreds of billions of neurons and glial cells, and something on the order of one quadrillion synaptic connections, all of which…


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