Magnetic resonance imaging-based cerebral tissue classification reveals distinct spatiotemporal …

Acute stroke model This study involved a retrospective analysis of data acquired previously as part of a study for which all procedures were approved by the Subcommittee for Research Animal Care (SRAC), the Institutional Animal Care and Use Committee (IACUC) of our institution that follows the National Institutes of Health Guide for the Care and Use of Laboratory Animals. Unilateral stroke was induced in seven adult male macaques (Macacca fascicularis, 7.7 ± 1.2 kg, 6–12 years old) by obstruction of the M1 branch of the middle cerebral artery (MCA) either by injection of a small volume of cyanoacrylate creating a permanent MCAo (n = 2), or by transient insertion of a micro infusion catheter. The catheter was subsequently removed after 3 h to effect reperfusion for a transient MCAo model (n = 5). Stroke induction followed procedures previously described…


Link to Full Article: Magnetic resonance imaging-based cerebral tissue classification reveals distinct spatiotemporal …