Loss of cells in brain’s memory center linked to schizophrenia

An image of the mouse hippocampus, with CA2 inhibitory neurons stained in light blue. In the researchers’ mouse model of schizophrenia, this region showed significant depletion of neurons and was accompanied by a deficit in social memory. Credit: Vivien Chevaleyre Scientists at Columbia University’s Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center (CUMC), and the Université Paris Descartes have found that deficits in social memory—a crucial yet poorly understood feature of psychiatric disorders such as schizophrenia—may be due to a decrease in the number of a particular class of brain cells, called inhibitory neurons, in a little-explored region within the brain’s memory center. The findings, which were reported today in the journal Neuron, explain some of the underlying mechanisms that lead to the more difficult-to-treat symptoms of…


Link to Full Article: Loss of cells in brain’s memory center linked to schizophrenia