June 2016

Compared to Wistar rats, naïve alcohol-preferring AA rats displayed lowered brain activity in the caudal linear nucleus (CLi) (Panels A and B). Alcohol drinking by AAs restored CLi activity (Panel B), and intra-CLi muscimol increased alcohol drinking (Panel C). These findings suggest that the mediocaudal region of the ventral tegmental area, particularly the CLi, plays an important role in mediating the propensity for high alcohol drinking and alcohol reward, possibly via GABAergic transmission.

Link to Full Article: June 2016