Increased Dosage of High-Affinity Kainate Receptor Gene grik4 Alters Synaptic Transmission and …

M. Isabel Aller, Valeria Pecoraro, Ana V. Paternain, Santiago Canals, and Juan Lerma Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas, Universidad Miguel Hernández de Elche, 03550 San Juan de Alicante, Spain Author contributions: M.I.A. and J.L. designed research; M.I.A., V.P., and A.V.P. performed research; S.C. contributed unpublished reagents/analytic tools; M.I.A., V.P., and A.V.P. analyzed data; J.L. wrote the paper. Abstract The understanding of brain diseases requires the identification of the molecular, synaptic, and cellular disruptions underpinning the behavioral features that define the disease. The importance of genes related to synaptic function in brain disease has been implied in studies describing de novo germline mutations and copy number variants. Indeed, de novo copy number variations (deletion or duplication of a chromosomal region) of synaptic genes have been recently implicated as…


Link to Full Article: Increased Dosage of High-Affinity Kainate Receptor Gene grik4 Alters Synaptic Transmission and …