Glial pathology in Alzheimer’s Disease: Insights from transgenic models and human post-mortem …

29 Jan [2016] at 13.00 CET Glial pathology in Alzheimer’s Disease: Insights from transgenic models and human post-mortem brains Antonia Gutiérrez Universidad de Málaga & CIBERNED AbstractNeuroinflammation is known as a key component in the neurodegenerative process of Alzheimer’s disease (AD), however the contribution of activated glial cells (microglia and astroglia) to the pathogenesis of this disease has not been fully dissected.  The actual view is based primarily on studies in transgenic mouse models of AD. We have shown previously that APP/PS1 mice hippocampus displays a switch in microglial activation phenotype in response to disease progression with a neuroprotective profile at early stages of the disease and neurotoxic at older ages. The switch from alternative to classical phenotype was associated to an increase in the hippocampal soluble oligomeric Aβ content.…


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