Genes, Schizophrenia, And Repairing The Brain

Researchhas linked the abnormal behavior of two genes (BDNF and DTNBP1) to the underlying cause of schizophrenia. These findings have provided a new target for schizophrenia treatment. Schizophrenia is a devastating mental disorder that affects nearly 1% of the total human population. The dominant cause of the disorder lies in impaired brain development that eventually leads to imbalanced signals within the brain. This imbalance within the brain is thought to cause hallucinations and paranoia in people with schizophrenia. “We wanted to understand the mechanism by which the brain circuit operates,” explained senior author Assistant Professor Shawn Je, from the Neuroscience and Behavioural Disorders Programme at Duke-NUS. “In particular, we wanted to understand the ability of a specific type of cell in the brain, termed interneurons, to modulate brain network activity…


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