Gene mutations shown to cause form of HSP

Scientists at the Montreal Neurological Institute and Hospital (MNI) have identified novel gene mutations that cause hereditary spastic paraplegia (HSP), a step forward in efforts to treat this debilitating disease. It is estimated that between two and 10 people per 100,000 in the general population have HSP, a disease characterized by weakness or spasticity in the lower limbs. HSP is caused by mutations inherited from one or both parents. While mutations in more than 70 genes are known or suspected to be responsible for HSP at the present time, many families remain undiagnosed, suggesting the causes of HSP are not entirely known. MNI researchers are part of a Canadian consortium of scientists (CanHSP) that analyze the DNA of patients with HSP. Two years ago MNI researchers identified one family with…


Link to Full Article: Gene mutations shown to cause form of HSP