FRET-FLIM optimization shows activity of two signaling molecules in single dendritic spine

VIDEO: This is a movie showing a dendritic segment of a layer 2/3 pyramidal neuron expressing GCaMP6s (blue) and CyRFP1 (red) during spontaneous calcium dynamics in the motor cortex of a… view more An ongoing challenge for scientists working to understand the brain is being able to see all its parts. Researchers have spent centuries developing better imaging techniques to see beyond the abilities of our naked eyes. They’ve built microscopes that gather information down to the electron level. They’ve engineered fluorescent tags that make cells and structures of interest more visible. One of the most effective imaging techniques for neuroscientists has been the combination of FRET (fluorescence resonance energy transfer) and FLIM (Fluorescence Lifetime Imaging Microscopy). This duo gives scientists the power to view biochemical dynamics of proteins with high…


Link to Full Article: FRET-FLIM optimization shows activity of two signaling molecules in single dendritic spine

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