Engraftment of enteric neural progenitor cells into the injured adult brain

The main objective of this study was to determine whether neural progenitor cells derived from the ENS could survive in the adult mammalian brain after transplantation and could have a potential role in repair of the injured CNS. We found that transplanted ENSCs survive, proliferate, and differentiate into neuronal and glial lineages in vivo. Moreover, transplanted cells migrate extensively along pre-existing pathways and modulate the local microenvironment to stimulate endogenous neurogenesis. We recently showed that Nestin-expressing neural progenitor cells can be isolated from the intestine and propagated in vitro to give rise to neurospheres capable of differentiating into neuronal and glial lineages [23]. These findings were confirmed in the present study. We have also previously shown that these neurospheres can generate enteric neurons upon transplantation into aneural embryonic hindgut [23].…


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