Elde, Robert, Ph.D.

Research in my laboratory aims to understand some of the cellular and molecular mechanisms that underlie neurotransmission. Synaptic neurotransmission is spatially precise and rapid in time course. In contrast, non-synaptic neurotransmission is less focal and is slower. In each case, neurons organize and deliver to the appropriate region of their plasma membrane the molecular machinery required for neurotransmitter packaging and release. Similarly, receptors and signal transduction molecules are delivered to appropriate regions of the plasma membrane of recipient neurons. We study models that represent each of these forms of neurotransmission. In the case of synaptic neurotransmission we have focused on the neurons that package adenosine triphosphate (ATP) into vesicles and release it to act upon neurons that express the P2X family of ATP-gated ion channels. We investigate non-synaptic neurotransmission through…


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