Dr. Matt Sarkisian & colleagues publish in Sept 2, 2016 Neuroscience

Neuroanatomical Characterization of the Cellular and Axonal Architecture of Subcortical Band Heterotopia in the BXD29-Tlr4lps-2J/J Mouse Cortex.  Ramos RL, Toia AR, Pasternack D, Dotzler TP, Cuoco JA, Esposito AW, Le M, Parker AK, Goodman JH, Sarkisian MR.   Neuroscience 2016. Abstract: Subcortical band heterotopia (SBH) are malformations of the human cerebral cortex typically associated with epilepsy and cognitive delay/disability. Rodent models of SBH have demonstrated strong face validity as they are accompanied by both cognitive deficits and spontaneous seizures or reduced seizure threshold. BXD29-Tlr4lps-2J/J recombinant inbred mice display striking bilateral SBH, partial callosal agenesis, morphological changes in subcortical structures of the auditory pathway, and display sensory deficits in behavioral tests (Rosen et al. 2013; Truong et al., 2013; 2015). Surprisingly, these mice show no cognitive deficits and have a higher…


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