Dopamine D 3 Receptors Modulate the Ability of Win-Paired Cues to Increase Risky Choice in

Michael M. Barrus and Catharine A. Winstanley Department of Psychology, University of British Columbia, Vancouver, British Columbia V6T1Z4, Canada Author contributions: M.M.B. and C.A.W. designed research; M.M.B. performed research; M.M.B. analyzed data; M.M.B. and C.A.W. wrote the paper. Abstract Similar to other addiction disorders, the cues inherent in many gambling procedures are thought to play an important role in mediating their addictive nature. Animal models of gambling-related behavior, while capturing dimensions of economic decision making, have yet to address the impact that these salient cues may have in promoting maladaptive choice. Here, we determined whether adding win-associated audiovisual cues to a rat gambling task (rGT) would influence decision making. Thirty-two male Long–Evans rats were tested on either the cued or uncued rGT. In these tasks, animals chose between four options…


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