Disrupting astrocyte–neuron lactate transfer persistently reduces conditioned responses to cocaine

Molecular Psychiatry advance online publication 27 October 2015; doi: 10.1038/mp.2015.157B Boury-Jamot1, A Carrard1, J L Martin1, O Halfon2, P J Magistretti1,3,4,5 and B Boutrel1,2,5 Top of page Introduction Drug memories that associate contextual cues with the effects of drugs of abuse are known to shape and maintain persistent drug-seeking behaviours in rodents.1 In abstinent humans, drug cues are known to evoke salient, persistent and overwhelming memories of drug-taking experiences, thereby inducing higher risks of craving and relapse.2, 3 Preclinical observations have long reported that, through predictive association with the drug’s effects, drug-conditioned stimuli can precipitate the reinstatement of previously extinguished drug-seeking behaviours.4, 5, 6 However, many questions remain to be answered about the mechanisms by which long-term memories for drug-paired cues resist extinction and contribute to the enhanced drive to take drugs. A large body of evidence suggests…


Link to Full Article: Disrupting astrocyte–neuron lactate transfer persistently reduces conditioned responses to cocaine