Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in …

Citation: Translational Psychiatry (2016) 6, e712; doi:10.1038/tp.2015.206Published online 12 January 2016D Tropea1,2,3, I Molinos1,2, E Petit4, S Bellini1,2, I Nagakura3, C O’Tuathaigh4, L Schorova1,2, K J Mitchell5, J Waddington4, M Sur3, M Gill1,2 and A P Corvin1,2 Top of page Introduction The major neuropsychiatric disorders (for example, schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder and attention deficit hyperactivity disorder) are substantially heritable and are of genetically complex etiology. Their etiology is polygenic, with evidence for a spectrum from common but small effects to rare, more highly penetrant mutations, together with environmental risk factors.1 Although age at onset varies across these disorders, from childhood (autism spectrum disorder, attention deficit hyperactivity disorder) to young adulthood (most cases of schizophrenia, major depressive disorder, bipolar disorder), they share not only overlapping symptoms and environmental risk factors, but also molecular etiology.2 Recent findings suggest that dysregulation of…


Link to Full Article: Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in …