Discovering New DNA Gyrase Inhibitors Using Machine Learning Approaches

Paper Discovering New DNA Gyrase Inhibitors Using Machine Learning Approaches Long Li, Xiu Le, Ling Wang, Qiong Gu, Huihao Zhou and Jun XuRSC Adv., 2015, Accepted Manuscript DOI: 10.1039/C5RA22568JReceived 28 Oct 2015, Accepted 04 Dec 2015First published online 07 Dec 2015    Send PDF to Kindle Request Permissions This content is free, please choose one of the three options provided in the Log in section to gain access. Please choose one of the options provided in the log in section to gain access to this content: The bacterial DNA gyrase is not expressed in eukaryotes. It is a promising target for broad-spectrum antibiotics. This paper reports new DNA gyrase inhibitors as broad-spectrum antibacterial agents discovered by means of target-based in silico and in vitro models. Two machine learning methods (naïve…


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