Dimensions of depressive symptoms and cingulate volumes in older adults

Citation: Translational Psychiatry (2016) 6, e788; doi:10.1038/tp.2016.49Published online 19 April 2016M E McLaren1, S M Szymkowicz1, A O’Shea2,3, A J Woods2,3,4, S D Anton2 and V M Dotson1,3,4 Top of page Introduction Multiple brain changes have been noted in fronto-limbic pathways in late-life depression, including structural and functional changes in gray matter and increased white matter hyperintensities.1, 2 Growing evidence suggests that subthreshold symptoms of depression have similar neural correlates as major depression in older adults, particularly in frontal regions.2, 3, 4, 5 The cingulate has been identified as a key area within fronto-limbic networks, in part based on its strong interconnectedness in pathways that are important for mood and emotional processing, including the orbitofrontal cortex, amygdala, hippocampus and striatum.6 Converging evidence from structural imaging, functional imaging and neuropathological studies confirm the role of the cingulate in the…


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