Developmental interneuron subtype deficits after targeted loss of Arx

Previous studies querying Arx function have shown an important role in interneuron development and suggested a role in both migration and cell differentiation [8, 22, 25, 26]. These studies employed a complete knockout of Arx to assess the ventral forebrain role of Arx, possibly complicating the analysis as dorsal progenitor function is also altered. Hence, to analyze the cell autonomous role of Arx in interneuron development we generated Arx conditional mutant mice with near complete loss of Arx from the ventral forebrain at e14.5 (embryonic day 14.5) in Arx−/Y ; Dlx5/6CIG males (Fig. 1A–A″, insets a″). In females there were radially oriented streams of Arx within and emerging from the GE ventricular zone, which varied dramatically between embryos (Fig. 1A′, insets). This apparent loss of some Arx cells dissipated when the Arx…


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