Ching-Kang Chen

 JoVE Neuroscience Hung-Ya Tu1, Chih-Chun Hsu1,2, Yu-Jiun Chen1, Ching-Kang Chen1,2,3 1Department of Ophthalmology, Baylor College of Medicine, 2Department of Neuroscience, Baylor College of Medicine, 3Department of Biochemistry and Molecular Biology, Baylor College of Medicine JoVE 54608 Nature Genetics. Oct, 2002  |  Pubmed ID: 12219089 Excessive phototransduction signaling is thought to be involved in light-induced and inherited retinal degeneration. Using knockout mice with defects in rhodopsin shut-off and transducin signaling, we show that two different pathways of photoreceptor-cell apoptosis are induced by light. Bright light induces apoptosis that is independent of transducin and accompanied by induction of the transcription factor AP-1. By contrast, low light induces an apoptotic pathway that requires transducin. We also provide evidence that additional genetic factors regulate sensitivity to light-induced damage. Our use of defined mouse mutants resolves some…


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