Cellular ‘switch’ helps brain distinguish safety from danger, new study finds

LRIP inhibitory neurons (in green) extending from the entorhinal cortex (lower right) into the hippocampus. LRIPs have been found to be part of a sophisticated mechanism that is critical to the formation of contextual memories. Credit: Jayeeta Basu Researchers at Columbia University’s Mortimer B. Zuckerman Mind Brain Behavior Institute and the Department of Neuroscience at Columbia University Medical Center (CUMC) have identified a cellular circuit that helps the mouse brain to remember which environments are safe, and which are harmful. Their study also reveals what can happen when that circuitry is disrupted—and may offer new insight into the treatment of conditions such as posttraumatic stress, panic and anxiety disorders. The researchers published their findings today in the journal Science. Learning and memory are among the brain’s most fundamental tools for…


Link to Full Article: Cellular ‘switch’ helps brain distinguish safety from danger, new study finds