Brain plasticity and cognitive functions after ethanol consumption in C57BL/6J mice

Citation: Translational Psychiatry (2015) 5, e696; doi:10.1038/tp.2015.183Published online 15 December 2015E Stragier1,2, V Martin1,2, E Davenas1,2, C Poilbout1,2, R Mongeau2,3, R Corradetti4 and L Lanfumey1,2 Top of page Introduction Drugs of abuse have been shown to alter synaptic plasticity and related neuronal function, and this damage is particularly important in case of alcohol.1 However, we recently reported, using adult C57BL/6J mice, that chronic and moderate ethanol consumption induced chromatin remodeling at histone level within the various promoters of the brain-derived neurotrophic factor (BDNF) through post-translational histone modifications.2 These epigenetic modifications were probably responsible, at least in part, for the increase in BDNF protein expression observed after such consumption and were associated to hippocampal neurogenesis stimulation controlled by BDNF TrkB receptor.2 In addition, it has been shown that DNA methylation that consists in the addition of a methyl group on…


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