BDNF–TrkB signaling in the nucleus accumbens shell of mice has key role in methamphetamine …

Citation: Translational Psychiatry (2015) 5, e666; doi:10.1038/tp.2015.157Published online 27 October 2015 Top of page Introduction Abuse of methamphetamine (METH) is a major public health problem. METH is a powerfully addictive stimulant associated with serious health risks such as cognitive impairment, aggression, psychotic symptoms and behavior, and potential heart and brain damage.1, 2, 3, 4, 5, 6 In humans, many psychiatric and psychological symptoms emerge after withdrawal from the repeated use of METH. Major METH withdrawal symptoms include depression (for example, anhedonia, dysphoria and anergia), agitation and irritability, fatigue (for example, increased sleeping and inactivity) and cognitive impairment. These symptoms may last from a few days to a few months.7 Withdrawal symptoms have been linked to a propensity for METH abuse relapse. METH-dependent subjects exhibit a wide range in the severity of depressive…


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