Baljit Khakh – November 13th

Categories: Events, INC, Seminars Neuroscience Seminar Series :  Friday, November 13th, 2015 at 11:30 am, Salle des Conférences (R229), Centre Universitaire des Saints-Pères, 45 rue des Saints-Pères, 75006 Paris Baljit Khakh, Professor, Department of Physology, David Geffen School of Medicine, UCLA Title: *Astrocyte dysfunction in neural circuits: focus on Huntington?sdisease* Brief description: We will report the detailed exploration of how earlyonset astrocyte dysfunction, without any evidence of accompanyingastrogliosis, drives disease in mouse models of Huntington?s disease (HD).The cellular mechanisms involve dysfunctional homeostasis and signalingmediated by Kir4.1, Glt1 and Ca2+. Our data directly show that the rulesfor astrocyte engagement in a neuronal circuit are altered in a braindisease caused by a known molecular defect, and that fixing early onsetastrocyte dysfunction can remedy cellular deficits. Overall, our data showthat key aspects of…


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