Are Bipolar-Related Sleep, Wake, and Activity Cycles Inherited?

An international study led by University of Texas Southwestern Medical Center and University of California, Los Angeles researchers indicates that more than a dozen traits related to sleep, wake, and activity cycles associated with severe bipolar disorder appear to be inherited. Published online on December 28, 2015 in Proceedings of the National Academy of Sciences, the research also links these traits with specific chromosomes that provide insight into the genetic nature of bipolar disorder and possible targets for prevention and treatment. The research is the first large-scale delineation of sleep and activity traits in people with bipolar disorder and their relatives and the first genetic investigation of a large set of sleep and circadian measures in any human study. “We were able to identify 13 sleep and activity measures, most of which…


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