April 2016

Searching for cognitive enhancement in the Morris water maze: better and worse performance in D-amino acid oxidase knockout (Dao−/−) mice (pages 979–989)David Pritchett, Amy M Taylor, Christopher Barkus, Sandra J Engle, Nicholas J Brandon, Trevor Sharp, Russell G Foster, Paul J Harrison, Stuart N Peirson and David M Bannerman Article first published online: 23 MAR 2016 | DOI: 10.1111/ejn.13192 D-amino acid oxidase (DAO) is an enzyme that degrades D-serine, an NMDA receptor co-agonist. Here, in DAO knockout mice, we report both better and worse Morris watermaze performance, depending on the radial distance of the hidden platform from the side wall of the pool. These results question the proposed relationship between DAO inactivation and enhanced long-term associative spatial memory. They also have generic implications for how Morris watermaze studies are performed…


Link to Full Article: April 2016