Animal-free screening platforms that predict toxicity on kidneys developed

SINGAPORE: Researchers in the Republic have developed the first animal-free screening platforms that can accurately predict the toxic effects of compounds on the human kidney. Instead of testing on animals, scientists make use of human renal cells, produced from human-induced pluripotent stem cells, together with machine-learning methods. “Our new kidney screening platforms will be very useful for many industries that require a reliable tool for evaluating the safety of compounds and ingredients,” said executive director Professor Jackie Ying of the Institute of Bioengineering and Nanotechnology (IBN), where the cell-based screening method was developed. Professor Ying cited examples such as the chemical and pharmaceutical industries, as well as the food industry. The new platform, which can also identify how the damage occurs to the kidneys, was announced by the Agency for…


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