Animal-Free Screening For Nephrotoxicity

By combining iPS cells with machine learning, researchers have developed an efficient and accurate screening platform to detect compounds that are toxic to the kidneys. Asian Scientist Newsroom | October 23, 2015 | In the Lab AsianScientist (Oct. 23, 2015) – Researchers from the Institute of Bioengineering and Nanotechnology (IBN) have developed the first animal-free screening platforms capable of predicting the toxic effects of compounds on the human kidney accurately. Their latest technological advancement, published in Scientific Reports, involved the use of human induced pluripotent stem cells (iPSCs). To realize this study, the scientists have developed an effective way of producing human renal cells from iPSCs, and have combined this with machine learning methods that improved the automated and accurate prediction of nephrotoxicity. In addition to predicting toxicity, the novel…


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